RAD-140, also known as Testolone, is an orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM) that has the ability to increase lean muscle mass and reinforce the effects of testosterone without the unwanted side effects of anabolic steroids.
Early studies and user reviews have delivered better results than steroid use with minimal side effects, making it one of the most exciting and powerful SARMs to date. Read on for a comprehensive review of everything you need to know about RAD 140, including benefits, side effects, studies and results for increasing muscle mass and preserving gains.
RAD140 is currently being developed by pharmaceutical company Radius. Its initial discovery was originally published in 2010, which means studies are limited. However, initial studies, company reports and anecdotal user reviews have been highly promising for building muscle without the side effects of anabolic steroids.
Discovered via an Internal Discovery Program, Testolone is actually being developed for the treatment of breast cancer and muscle wasting in postmenopausal women. According to the company’s website, the FDA accepted their Investigational New Drug Application and the first human clinical trial was expected to begin in 2017.
How RAD140 Works
The androgen receptor (AR) primarily targets normal human sexual development, but its activation by compounds (such as testosterone) also effects bone, muscle, liver and the central nervous system.
The problem within the medical and bodybuilding communities is that using testosterone to activate AR signaling for increased muscle and bone development also affects the sex tissues, resulting in testicular atrophy, enlarged clitoris in females and even risks of prostate cancer. 
RAD140, a nonsteroidal selective androgen receptor modulator (SARM) bypasses this issue. Due to the way RAD140 binds to the androgen receptor, different cells respond by releasing different proteins, with only some androgen receptors being activated throughout the body.
This stimulation results in androgen receptor activation in bone and muscle cell, rather than raising liver enzymes or affecting sexual tissue.
According to the Cambridge-based pharmaceuticals company Radius:
“…The potent, orally bioavailable and nonsteroidal RAD 140 is designed to make the hormonal receptors in the tissues of the body act as if they’re getting a good dose of testosterone, setting off the same effects of prohormones and anabolic steroids minus the unwanted side effects…”
There are 8 primary benefits that have been observed in both initial studies and user-reported reviews.
1. RAD-140 helps increase muscle mass
The number one benefit of supplementing with RAD140 is its ability to increase lean tissue without increasing fat. In fact, during initial studies done on monkeys, scientists observed an average weight gain of more than 10% in just 28 days. This was done using only RAD 140 and without any adverse side effects traditionally related to testosterone.
2. RAD-140 may enhance speed, stamina and endurance during high-intensity workouts
Want to work out longer, harder and get better results every time you hit the gym? Reports of enhanced speed, stamina and endurance during workouts are common when supplementing with Testolone. Additionally, thanks to its ability to increase lean muscle tissue and decrease fat, high-intensity workouts and interval training can be optimized every time.
3. RAD-140 has a greater anabolic effect than testosterone
Similar to other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces similar results to testosterone but without the side effects.
RAD-140 interacts with the hormonal receptors of muscle and bone tissue in the same ways as larger doses of testosterone, all without the estrogenic side effects caused by anabolic steroids.
Many users on forums also report greater anabolic effects than testosterone and is sometimes used as a PCT for steroid users to retain muscle mass between cycles.
4. RAD140 may reduce the side effects of testosterone
When taken in conjunction with anabolic steroids, initial studies indicated that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys .
Additionally, many anabolic steroid users report concerns for the health of their liver. However, during the 28-day trial, these monkeys also showed minimal liver enzyme elevations on a dose 10x higher than the fully effective dose, even though the weight was gained during a short timeframe (which can cause liver strain).
Our advice? With the results from RAD140 already proving better than anabolic steroid use, users may be better off forgetting testosterone altogether and sticking to SARMs.
5. Testolone does not appear to have the same side effects of anabolic steroids on reproductive organs
Initial studies on mice have found that low doses of RAD140 is all that’s needed to stimulate muscle growth without affecting the weight of the prostate.
This means that RAD140 has the ability to selectively stimulate muscle and bone growth while reducing the effects on sex tissue such as the prostate or clitoris. (So yes, this means RAD140 is safe for women)
6. RAD140 may aid weight loss by increasing fat loss
RAD140 indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, in the increase in the metabolism is seen, which results in easier weight loss .
Users also report increased muscle growth and decreased fat stores thanks to RAD140’s ability to increase stamina, endurance, and speed during an interval training.
7. RAD140 is being trialed for the treatment of breast cancer
RAD140 was discovered and is currently being developed by pharmaceutical company Radius specifically for the treatment of Androgen Receptor (AR) and Estrogen Receptor Positive (ER+) breast cancer in postmenopausal women.
In vitro studies completed in 2017 showed that RAD140 inhibited the growth of AR/ER+ breast cancer cells. Results from these studies supported further investigation of RAD140 as a breast cancer treatment, and the first human clinical trials were brought forward .
8. RAD140 is indicated to be neuroprotective for brain health in neurodegenerative diseases
As testosterone levels in men decline, the risk of disease in androgen-responsive tissue (including the brain) increases, implicating the development of neurodegenerative diseases such as Alzheimer’s Disease.
TRY NOW! www.hardcoreshoppe.com